Vol. 8, Issue 2, Part A (2024)

The autosomal dominant condition known as neurofibromatosis type 1 is typified by neurofibromas tumors, which are renowned for being many cutaneous masses with a strong likelihood of becoming malignant. On the other hand, benign solitary retroperitoneal neurofibromas (SRN) are rare and manifest alone, without coexisting medical conditions.

This 41-year-old woman complained of a painless lump in the left side of her lower abdomen that had been there for a month when she arrived at the general surgery outpatient department. A solid, non-tender, palpable oval shaped lesion measuring 10 x 7 cm with restricted movements was noted in the left lumbar region. The ultrasonography showed a well-defined hyperechoic lesion with anechoic areas measuring 9.7 X 7.2 cm in the left iliac fossa with internal vascularity.

According to an MRI, there is a large lobulated retroperitoneal mass lesion on the left side at the level of L3 L4 L5 vertebral body levels in the paravertebral area. USG-guided biopsy showed Spindle cells with a plump, buckling nucleus, minimal pleomorphic, and mitotic activity (S100 - > 80% positive) comprise the tumour tissue of a neurofibroma. This retroperitoneal neurofibromas is excised via a conventional open surgery. This case reports presents a rare case of giant neurofibroma presenting as a retroperitoneal tumour, a rare incidence.